of chronic diseases are rooted in lifestyle drivers that can be addressed with precision genomics.
Our Science
Genes First precision turns lifestyle-driven chronic disease into a solvable challenge.
Lifestyle factors drive the majority of chronic disease, yet patients and practitioners still wrestle with guesswork. The 3X4 Genetics test decodes the pathways behind weight, inflammation, and metabolic resilience so every intervention is personal, proactive, and proof-backed.
2.2 billion people worldwide are already living with obesity. Genes First insight helps teams move faster than the risk curve.
Insights extracted from the 3X4 Science Deck 2025.
of global deaths trace back to diseases linked to chronic inflammation—3X4 pinpoints the pathways that fuel it.
The 3X4 Genetics test pinpoints chronic disease predisposition, takes the guesswork out of weight management, and exposes the root causes of inflammation.
The future of healthcare
Patients and physicians are ready for personalized, Genes First care.
A Medscape survey of 1,000 U.S. primary care physicians and a companion consumer study on 1,501 Americans confirm the demand: people want genomics woven into routine care, and clinicians see the value—yet adoption still lags.
of individuals say they would embrace care tailored to their genetic profile.
of physicians acknowledge genetics as essential to a complete health picture, but need tools and support to deploy it.
Only two in ten people in the U.S. have taken a genetic test, leaving a wide-open opportunity for practices that lead.
Why personalization works
A Genes First formula aligns every recommendation to what the body actually needs.
Genes (G) describe the inherent blueprint, environment (E) tells the story of inputs and stressors, and together they guide precise health outcomes (P). Overlay 3X4 insights and clinicians can see—and address—the root causes.
Genetics
176 SNPs mapped to functional impact across 36 metabolic pathways reveal each patient’s predispositions.
Environment
Nutrition, lifestyle, and exposures either amplify or calm those predispositions—and the Blueprint shows by how much.
Personalized Healthcare
Tailored protocols for weight, inflammation, hormones, tissue repair, metabolism, and cognition build resilient outcomes.
Why 3X4
The Genes First blueprint spans every major health domain.
With one cheek-swab test, practitioners gain a panoramic view of the body’s interlinked systems and how to keep them in harmony.
Weight Balance
Identify metabolic bottlenecks and tailor programs that dissolve plateaus.
Blood Sugar
Surface genetic influences on glucose handling to avert compounding risk.
Brain Health
Address neuroinflammation and neurotransmitter pathways before symptoms escalate.
Fitness & Tissue Health
Guide recovery, connective tissue resilience, and performance with genomic certainty.
Hormone Balance
Decode estrogen, androgen, and stress pathways that steer energy and mood.
Heart Health
Spot lipid, inflammatory, and detox dynamics to protect cardiovascular longevity.
Genotyping technology
Built with Thermo Fisher Scientific for precision, scale, and inclusivity.
The 3X4 test runs on a custom Axiom microarray constructed on the Precision Medicine Diversity Array (PMDA), tapping more than 850,000 markers for dense global genomic coverage.
Diverse genomic intelligence
Variants are sourced from 1000 Genomes, ClinVar, GWAS, CPIC, PharmaGKB, and PharmaADME, then refined with nutrigenomic markers unique to 3X4.
Cross-ancestry accuracy
Rigorous testing across HapMap datasets—including African, European, East/South Asian, and admixed American populations—ensures dependable reads for every ancestry.
Global references
Integration with gnomAD and the Qatar Genome Program keeps the assay responsive to regional variants and population frequencies.
Shared pathways, local context
Inflammation, detoxification, methylation, hormone balance, and insulin signaling pathways are conserved across populations. 3X4 ensures they are interpreted through a culturally relevant lens, including Middle Eastern and Arabian Peninsula communities.
Patented methodology
Evidence-led variant selection and pathway-based scoring.
3X4’s Darwin methodology gives practitioners an accessible window into complex polygenic interactions, translating genomic data into ready-to-implement guidance.
Functional effect first
Gene variants are chosen when they drive meaningful shifts in how nutrients and metabolites are processed.
Patented weighting
Darwin quantifies the impact of each variant across multiple pathways, prioritizing clinical relevance.
Polygenic clarity
Weighted scores reveal how combinations of genes influence 36 metabolic domains, guiding high-impact interventions.
Designed for clinicians
Reports, guidance, and community that keep every consult collaborative.
3X4 surrounds the Blueprint with education, mentorship, and ready-to-share assets so teams stay confident from the first consult through long-term maintenance.
Language of color
Dynamic visuals help patients grasp their status instantly while practitioners annotate strategies in real time.
Searchable insight
Find the highest impact areas in seconds, jump to connected pathways, and link directly to the 3X4 Clinical Guide.
Everything one click away
Deep dives on every SNP include associated pathways, conditions, diet, supplements, and population frequencies.
Award-winning network
7,000+ healthcare practitioners collaborate in the 3X4 community, supported 24/7 with mentorship, courses, and marketing resources.
Practitioner perspective
How precision health actually works in practice.
Hear from our Head of Health Impact & Integration, Annelie Smith RD, IFNCP, on how 3X4 Genetics brings genes, nutrition, and lifestyle together into clear, actionable insights—helping practitioners work upstream, identify root causes, and deliver truly personalized care.
See how the 3X4 Blueprint translates genetic complexity into practical, patient-ready decisions.
Practitioner testimonials
Science-driven partners see tangible practice transformation.
3X4 practitioner spotlights
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Elizabeth W. Boham, MD, MS, RD
“The 3X4 Genetics test panel is an invaluable tool to help determine where to focus in caring for our patients. By knowing each patient’s SNPs, we can customize a treatment plan that helps our patients reach their health goals.”
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Frank Lipman, MD
“We have been attending monthly mentorship sessions with the 3X4 Mentorship team. These ladies have not only assisted us with gaining confidence in our interpretation of reports and SNPs but also the clinical translation of these. This has allowed us to put GENES FIRST in our clinic, meaning all patients who come through our doors are required to do a 3X4 Genetics test so we can personalize their interventions. This is a game changer in personalized longevity medicine.”
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Maggie Ward MS, RD, LDN
“I have used other nutrigenomic labs before, but 3X4 by far has been the most insightful. The reports are robust, research based, and the information is presented in a way that is not overwhelming for the clinician nor the patient. Their online clinical guide and interactive reports are excellent and integrate a lot of information that is easy to access quickly. I now recommend this lab for most of my clients to help me provide dietary plans that have taken personalized nutrition to a new level!”
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Leslie Edmunds
“The clinic mentorship sessions have been transformational in our understanding of nutrigenomics and the 3X4 framework. What an amazing opportunity to be able to pick the brains of these nutrigenomics experts. These sessions have improved our knowledge and pushed us to further understand the human body. We’re helping more people feel their best, the ultimate goal of our practice.”
